Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR005108)
Formula
SVG example
Reactant Hydralazine pyruvate hydrazone Product Phthalazinone
Reactant Info Product Info
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Produce The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR005104 Hydralazine pyruvate hydrazone Hydralazine pyruvate hydrazone Unclear Hydralazine hydrochloride [1], [2]
MR005106 Hydralazine pyruvate hydrazone tricyclic dehydration product Hydralazine pyruvate hydrazone Unclear Hydralazine hydrochloride [3]
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR005107 Hydralazine pyruvate hydrazone Hydralazine acetone hydrazone Unclear Hydralazine hydrochloride [4], [5]
MR005104 Hydralazine pyruvate hydrazone Hydralazine pyruvate hydrazone Unclear Hydralazine hydrochloride [1], [2]
MR005105 Hydralazine pyruvate hydrazone Hydralazine pyruvate hydrazone tricyclic dehydration product Unclear Hydralazine hydrochloride [3]
Other MR(s) Related to The Product of This MR
Other MR(s) That Produce The Product of This MR
MR ID Reactant Product MR Type Related Drug REF
MR005101 Alpha-ketoglutarate hydrazone Phthalazinone Unclear Hydralazine hydrochloride [1]
MR005099 Phthalazine Phthalazinone Unclear Hydralazine hydrochloride [1]
References
1 Metabolism of hydralazine: relevance to drug-induced lupus
2 Quantitative analysis of hydralazine pyruvic acid hydrazone, the major plasma metabolite of hydralazine
3 DrugBank(Pharmacology-Metabolism):Hydralazine
4 Hypotensive effect of the hydralazine--acetone hydrazone in conscious rabbits: evidence for its back-conversion to hydralazine in vivo
5 Pharmacokinetics and biotransformation of hydralazine acetone hydrazone, a metabolite of hydralazine, in the rat

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