Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR005162)
Formula Reactant M2 (piperaquine) Product Piperaquine metabolite M6
Reactant Info Product Info
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Produce The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR005160 Piperaquine M2 (piperaquine) Oxidation - N-oxidation Piperaquine [1], [2], [3]
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR005161 M2 (piperaquine) M5 (piperaquine) Oxidation - N-oxidation Piperaquine [1], [2]
Other MR(s) Related to The Product of This MR
Other MR(s) That Produce The Product of This MR
MR ID Reactant Product MR Type Related Drug REF
MR005164 Byproduct (piperaquine) Piperaquine metabolite M6 Oxidation - N-oxidation Piperaquine [1], [2]
References
1 Characterization of human urinary metabolites of the antimalarial piperaquine
2 Metabolite identification of the antimalarial piperaquine in vivo using liquid chromatography-high-resolution mass spectrometry in combination with multiple data-mining tools in tandem
3 In vitro metabolism of piperaquine is primarily mediated by CYP3A4

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