Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR005163)
Formula
SVG example
N-dealkylation
Reactant Piperaquine Product Byproduct (piperaquine)
Reactant Info Product Info
Metabolic Type Oxidation - N-dealkylation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR005165 Piperaquine M1 (piperaquine) Oxidation - N-dealkylation Piperaquine [1], [2]
MR005160 Piperaquine M2 (piperaquine) Oxidation - N-oxidation Piperaquine [1], [2], [3]
MR005168 Piperaquine M3 (piperaquine) Oxidation - Hydrolyzationn Piperaquine [1]
MR005167 Piperaquine M7 (piperaquine) Oxidation - Hydrolyzationn Piperaquine [1]
Other MR(s) Related to The Product of This MR
Other MR(s) That Metabolize The Produtc of This MR
MR ID Reactant Product MR Type Related Drug REF
MR005164 Byproduct (piperaquine) Piperaquine metabolite M6 Oxidation - N-oxidation Piperaquine [1], [2]
References
1 Characterization of human urinary metabolites of the antimalarial piperaquine
2 Metabolite identification of the antimalarial piperaquine in vivo using liquid chromatography-high-resolution mass spectrometry in combination with multiple data-mining tools in tandem
3 In vitro metabolism of piperaquine is primarily mediated by CYP3A4

If you find any error in data or bug in web service, please kindly report it to Dr. Yin and Dr. Li.