Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR005190)
Formula
SVG example
N-dealkylation
Reactant Proguanil Product 4-Chlorophenylbiguanide
Reactant Info Product Info
Metabolic Enzyme Mephenytoin 4-hydroxylase (CYP2C19) DME Info
Metabolic Type Oxidation - N-dealkylation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR005189 Proguanil Cycloguanil Other reaction - Cyclisation Proguanil [1], [2], [3]
References
1 In vitro proguanil activation to cycloguanil is mediated by CYP2C19 and CYP3A4 in adult Chinese liver microsomes. Acta Pharmacol Sin. 2000 Aug;21(8):747-52.
2 Sensitive method for the quantitative determination of proguanil and its metabolites in rat blood and plasma by liquid chromatography-mass spectrometry
3 Single dose pharmacokinetics of proguanil and its metabolites in pregnancy

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