Details of the Metabolic Reaction (MR) | INTEDE

General Information of This Metabolic Reaction (MR) (ID: MR005236)
Formula	UGT1A3 ... Glucuronidation
	Reactant	Retigabine		Product	Retigabine-N2-glucuronide
	Reactant	Reactant Info		Product	Product Info
Metabolic Enzyme	UDP-glucuronosyltransferase 1A3 (UGT1A3)					DME Info
	UDP-glucuronosyltransferase 1A4 (UGT1A4)					DME Info
	UDP-glucuronosyltransferase 1A9 (UGT1A9)					DME Info
Metabolic Type	Conjugation - Glucuronidation

Other MR(s) Related to The Reactant of This MR

Other MR(s) That Metabolize The Reactant of This MR

MR ID	Reactant	Product	MR Type	Related Drug	REF
MR005238	Retigabine	N-Acetyl Retigabine	Conjugation - N-acetylation	Retigabine	[1]
MR005237	Retigabine	Retigabine-N4-glucuronide	Conjugation - Glucuronidation	Retigabine	[1], [2], [3]

References
1	Retigabine: the newer potential antiepileptic drug
2	Retigabine N-glucuronidation and its potential role in enterohepatic circulation. Drug Metab Dispos. 1999 May;27(5):605-12.
3	N-Glucuronidation of the antiepileptic drug retigabine: results from studies with human volunteers, heterologously expressed human UGTs, human liver, kidney, and liver microsomal membranes of Crigler-Najjar type II. Metabolism. 2006 Jun;55(6):711-21.

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