Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR005271)
Formula Reactant Tegafur-uracil Product 5-hydroxytegafur
Reactant Info Product Info
Metabolic Enzyme Cytochrome P450 2A6 (CYP2A6) DME Info
Metabolic Type Oxidation - Hydrolyzationn
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR005279 Tegafur-uracil 3-hydroxytegafur Oxidation - Hydrolyzationn Tegafur-uracil [1]
MR005280 Tegafur-uracil 4-hydroxytegafur Oxidation - Hydrolyzationn Tegafur-uracil [1]
MR005281 Tegafur-uracil Dihydrotegafur Oxidation - Hydrolyzationn Tegafur-uracil [2], [3], [4]
Other MR(s) Related to The Product of This MR
Other MR(s) That Metabolize The Produtc of This MR
MR ID Reactant Product MR Type Related Drug REF
MR005272 5-hydroxytegafur Fluorouracil Multi-steps Reaction - Hydrolysis; oxidation Tegafur-uracil [1]
References
1 DrugBank(Pharmacology-Metabolism):Tegafur-uracil
2 Summary of information on human CYP enzymes: human P450 metabolism data. Drug Metab Rev. 2002 Feb-May;34(1-2):83-448.
3 Roles of cytochromes P450 1A2, 2A6, and 2C8 in 5-fluorouracil formation from tegafur, an anticancer prodrug, in human liver microsomes. Drug Metab Dispos. 2000 Dec;28(12):1457-63.
4 Comparative pharmacology of oral fluoropyrimidines: a focus on pharmacokinetics, pharmacodynamics and pharmacomodulation

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