Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR005303)
Formula
UGT1A4 ...
SVG example
Glucuronidation
Reactant Cotinine Product Cotinine-N-glucuronide
Reactant Info Product Info
Metabolic Enzyme UDP-glucuronosyltransferase 1A4 (UGT1A4) DME Info
UDP-glucuronosyltransferase 1A9 (UGT1A9) DME Info
Metabolic Type Conjugation - Glucuronidation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR005302 Cotinine 3'-hydroxycotinine Oxidation - Hydrolyzationn Cotinine [1], [2]
MR005305 Cotinine Cotinine-N-oxide Oxidation - Oxdation Cotinine [3]
MR005304 Cotinine Norcotinine Oxidation - N-demethylation Cotinine [4]
MR005300 Cotinine Trans-3'-hydroxycotinine Oxidation - Hydrolyzationn Cotinine [4]
MR002966 Cotinine 3'-hydroxycotinine Oxidation - 3'-Hydroxylation Nicotine [5]
MR002967 Cotinine Cotinine N-oxide metabolite Oxidation - N-Oxidation Nicotine [5]
MR002968 Cotinine Nicotine-1'-N-oxide Oxidation - 1'-N-Oxidation Nicotine [5]
MR002965 Cotinine Nornicotine Unclear Nicotine [6]
References
1 Characterization and comparison of nicotine and cotinine metabolism in vitro and in vivo in DBA/2 and C57BL/6 mice
2 Metabolism of nicotine and cotinine by human cytochrome P450 2A13. Drug Metab Dispos. 2005 Feb;33(2):258-61.
3 Increased cotinine elimination and cotinine-N-oxide formation by phenobarbital induction in rat and mouse
4 Interindividual variability in nicotine metabolism: C-oxidation and glucuronidation
5 Pharmacogenomics knowledge for personalized medicine Clin Pharmacol Ther. 2012 Oct;92(4):414-7. doi: 10.1038/clpt.2012.96.
6 DrugBank(Pharmacology-Metabolism)Nicotine

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