Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR005315)
Formula
SVG example
Reactant Coumarin Product O-Hydroxyphenylethanol
Reactant Info Product Info
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR005310 Coumarin 3-Hydroxycoumarin Oxidation - Aromatic hydroxylation Coumarin [1]
MR005311 Coumarin 4-Hydroxycoumarin Oxidation - Hydrolyzationn Coumarin [2]
MR005312 Coumarin 5-Hydroxycoumarin Oxidation - Hydrolyzationn Coumarin [2]
MR005313 Coumarin 6-Hydroxycoumarin Oxidation - Hydrolyzationn Coumarin [2]
MR005309 Coumarin 7-Hydroxycoumarin Oxidation - Hydroxy Aromaticlation Coumarin [1], [3]
MR005314 Coumarin 8-Hydroxycoumarin Oxidation - Hydrolyzationn Coumarin [2]
MR005306 Coumarin Coumarin 3,4-epoxide Oxidation - Epoxidation Coumarin [1]
MR005316 Coumarin O-Hydroxyphenyl-propionic Acid Unclear Coumarin [2]
References
1 Identification of the cytochromes P450 that catalyze coumarin 3,4-epoxidation and 3-hydroxylation
2 Coumarin metabolism by rat esophageal microsomes and cytochrome P450 2A3
3 Species differences and interindividual variation in liver microsomal cytochrome P450 2A enzymes: effects on coumarin, dicumarol, and testosterone oxidation

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