Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR005435)
Formula Reactant Bempedoic acid Product ETC-1002-CoA
Reactant Info Product Info
Metabolic Enzyme Very long-chain acyl-CoA synthetase (SLC27A2) DME Info
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR005432 Bempedoic acid ESP15228 Unclear Bempedoic acid [1], [2]
MR005443 Bempedoic acid ETC-1002-glucuronide Unclear Bempedoic acid [2]
MR005444 Bempedoic acid ETC-1002-sulfate Unclear Bempedoic acid [2]
MR005439 Bempedoic acid Hydroxymethyl-ETC-1002 Unclear Bempedoic acid [2]
Other MR(s) Related to The Product of This MR
Other MR(s) That Metabolize The Produtc of This MR
MR ID Reactant Product MR Type Related Drug REF
MR005436 ETC-1002-CoA ETC-1002-taurine Unclear Bempedoic acid [2]
MR005438 ETC-1002-CoA Glucuronide conjugates Unclear Bempedoic acid [3]
References
1 Measurement of bempedoic acid and its keto metabolite in human plasma and urine using solid phase extraction and electrospray LC-MS/MS
2 The Disposition and Metabolism of Bempedoic Acid, a Potent Inhibitor of ATP Citrate Lyase, in Healthy Human Subjects
3 DrugBank(Pharmacology-Metabolism):Bempedoic acid

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