Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR005516)
Formula Reactant Infigratinib Product Infigratinib M2
Reactant Info Product Info
Metabolic Type Oxidation - N-Dealkylation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR005515 Infigratinib Infigratinib M1 Oxidation - O-Demethylation Infigratinib [1]
MR005518 Infigratinib Infigratinib M11 Unclear Infigratinib [1]
MR005517 Infigratinib Infigratinib M3 Other reaction - N-ethyl piperazine ring Infigratinib [1]
MR005514 Infigratinib Unclear Oxidation - Hydrolyzationn Infigratinib [2], [3]
References
1 Identification and characterization of in silico, in vivo, in vitro, and reactive metabolites of infigratinib using LC-ITMS: bioactivation pathway elucidation and in silico toxicity studies of its metabolites
2 Infigratinib Is a Reversible Inhibitor and Mechanism-Based Inactivator of Cytochrome P450 3A4
3 Identification of Infigratinib as a Potent Reversible Inhibitor and Mechanism-Based Inactivator of CYP2J2: Nascent Evidence for a Potential In Vivo Metabolic Drug-Drug Interaction with Rivaroxaban

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