Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR005528)
Formula
SVG example
N-Demethylation
Reactant Lurbinectedin Product Lurbinectedin Metablite 6
Reactant Info Product Info
Metabolic Type Oxidation - N-Demethylation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR005531 Lurbinectedin Lurbinectedin Metablite 1 Unclear Lurbinectedin [1]
MR005526 Lurbinectedin Lurbinectedin Metablite 2 Oxidation - O-Demethylation Lurbinectedin [1]
MR005530 Lurbinectedin Lurbinectedin Metablite 4 Other reaction - Aliphatic ring opening Lurbinectedin [1]
MR010036 Lurbinectedin Lurbinectedin Metabolite M1 Unclear - Unclear Lurbinectedin [1]
MR010037 Lurbinectedin Lurbinectedin Metabolite M2 Unclear - Unclear Lurbinectedin [1]
MR010038 Lurbinectedin Lurbinectedin Metabolite M4 Unclear - Unclear Lurbinectedin [1]
MR010039 Lurbinectedin Lurbinectedin Metabolite M6 Unclear - Unclear Lurbinectedin [1]
Other MR(s) Related to The Product of This MR
Other MR(s) That Metabolize The Produtc of This MR
MR ID Reactant Product MR Type Related Drug REF
MR005529 Lurbinectedin Metablite 6 Lurbinectedin Metablite 1 Unclear Lurbinectedin [1]
References
1 Metabolic Disposition of Lurbinectedin, a Potent Selective Inhibitor of Active Transcription of Protein-Coding Genes, in Nonclinical Species and Patients

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