Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR005670)
Formula
UGT
SVG example
Glucuronidation
Reactant LU-AA34443 Product LU-AA34443 Glucuronide Metabolite
Reactant Info Product Info
Metabolic Enzyme UDP-glucuronyltransferase (UGT) DME Info
Metabolic Type Conjugation - Glucuronidation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Produce The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR005669 Vortioxetine Metabolite 1 LU-AA34443 Oxidation - Carboxylation Vortioxetine hydrobromide [1], [2]
Other MR(s) Related to The Product of This MR
Other MR(s) That Produce The Product of This MR
MR ID Reactant Product MR Type Related Drug REF
MR005672 LU-AA39835 LU-AA34443 Glucuronide Metabolite Conjugation - Glucuronidation Vortioxetine hydrobromide [1], [2]
References
1 Identification of the cytochrome P450 and other enzymes involved in the in vitro oxidative metabolism of a novel antidepressant, Lu AA21004. Drug Metab Dispos. 2012 Jul;40(7):1357-65.
2 Vortioxetine: clinical pharmacokinetics and drug interactions. Clin Pharmacokinet. 2018 Jun;57(6):673-686.

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