Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR005708)
Formula
SVG example
Hydrolysis
Reactant Bromocriptine mesylate Product Bromolysergic acid
Reactant Info Product Info
Metabolic Enzyme Cytochrome P450 3A4 (CYP3A4) DME Info
Metabolic Type Hydrolysis - Hydrolysis
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR005709 Bromocriptine mesylate Bromoisolysergic acid Hydrolysis - Hydrolysis Bromocriptine mesylate [1], [2], [3]
References
1 Fate and disposition of bromocriptine in animals and man. II: Absorption, elimination and metabolism
2 Fate and disposition of bromocriptine in animals and man. I: structure elucidation of the metabolites
3 Contribution of cytochrome P450 3A pathway to bromocriptine metabolism and effects of ferrous iron and hypoxia-re-oxygenation on its elimination in the perfused rat liver

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