Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR005781)
Formula Reactant Naloxegol oxalate Product N-Dealkylated-mPEG7-Naloxol
Reactant Info Product Info
Metabolic Type Oxidation - N-dealkylation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR005780 Naloxegol oxalate Carboxymethyl-PEG6-Naloxol Oxidation - Oxidationn Naloxegol oxalate [1], [2]
MR005778 Naloxegol oxalate HO-PEG4-Naloxol Oxidation - Hydrolyzationn Naloxegol oxalate [1], [2]
MR005776 Naloxegol oxalate HO-PEG5-Naloxol Oxidation - Hydrolyzationn Naloxegol oxalate [1], [2]
References
1 Absorption, distribution, metabolism, and excretion of [14C]-labeled naloxegol in healthy subjects
2 Naloxegol: treatment for opioid-induced constipation in chronic non-cancer pain. Ann Pharmacother. 2015 Mar;49(3):360-5.

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