Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR005866)
Formula
SVG example
Reactant Liothyronine Product Reverse triiodothyronine
Reactant Info Product Info
Metabolic Enzyme Thyroxine 5-deiodinase (DIO3) DME Info
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR001574 Liothyronine Diiodothyronine Oxidation - Dehalogenation Liothyronine [1]
MR001577 Liothyronine Iodine Unclear Liothyronine [2]
MR001576 Liothyronine Tiratricol Oxidation - Deamination Liothyronine [2]
MR001575 Liothyronine Triiodothyronine sulfate Conjugation - Conjugation Liothyronine [1]
MR005868 Liothyronine 3, 3'-T2 Unclear L-thyroxine [3]
MR005867 Liothyronine Diiodothyronine Unclear L-thyroxine [3]
Other MR(s) Related to The Product of This MR
Other MR(s) That Produce The Product of This MR
MR ID Reactant Product MR Type Related Drug REF
MR001518 Levothyroxine sodium Reverse triiodothyronine Oxidation - Deiodination Levothyroxine sodium [4]
Other MR(s) That Metabolize The Produtc of This MR
MR ID Reactant Product MR Type Related Drug REF
MR001516 Reverse triiodothyronine Diiodothyronine Oxidation - Deiodination Levothyroxine sodium [5]
References
1 DrugBank(Pharmacology-Metabolism)Liothyronine
2 Ashley C. and Dunleavy A. (2014). The renal drug handbook. Caroline Ashley and Aileen Dunleavy.
3 Lipoatrophic diabetes: endocrine dysfunction and the response to control hypertriglyceridemia
4 Local activation and inactivation of thyroid hormones: the deiodinase family Mol Cell Endocrinol. 1999 May 25;151(1-2):103-19. doi: 10.1016/s0303-7207(99)00040-4.
5 LABEL:EVOTHYROXINE SODIUM injection

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