Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR006022)
Formula
SVG example
Reactant Oxolithocholic acid Product CA
Reactant Info Product Info
Metabolic Enzyme 12alpha-hydroxysteroid dehydrogenase (12-HSDH) DME Info
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR006020 Oxolithocholic acid 7,12-dioxo-LCA Unclear Oxolithocholic acid [1]
Other MR(s) Related to The Product of This MR
Other MR(s) That Produce The Product of This MR
MR ID Reactant Product MR Type Related Drug REF
MR002545 Chenodeoxycholic acid Cholic acid Unclear Chenodeoxycholic acid [2]
MR005331 Dehydrocholic acid Cholic acid Reduction - Reduction Dehydrocholic acid [3], [4]
MR013677 Deoxycholic acid CA Oxidation - 7-hydroxylation Deoxycholic acid [5]
Other MR(s) That Metabolize The Produtc of This MR
MR ID Reactant Product MR Type Related Drug REF
MR006023 CA 7-oxo-DCA Unclear Oxolithocholic acid [1]
References
1 Metabolism of oxo-bile acids and characterization of recombinant 12alpha-hydroxysteroid dehydrogenases from bile acid 7alpha-dehydroxylating human gut bacteria. Appl Environ Microbiol. 2018 May 1;84(10). pii: e00235-18.
2 Conversion of chenodeoxycholic acid to cholic acid by human CYP8B1. Biol Chem. 2019 Apr 24;400(5):625-628.
3 Triketocholanoic (dehydrocholic) acid. Hepatic metabolism and effect on bile flow and biliary lipid secretion in man
4 Identification, cloning, heterologous expression, and characterization of a NADPH-dependent 7beta-hydroxysteroid dehydrogenase from Collinsella aerofaciens. Appl Microbiol Biotechnol. 2011 Apr;90(1):127-35.
5 Deoxycholic acid transformations catalyzed by selected filamentous fungi

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