Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR006028)
Formula Reactant Bedaquiline fumarate Metabolite M2 Product Bedaquiline fumarate Metabolite M3
Reactant Info Product Info
Metabolic Type Oxidation - N-demethylation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Produce The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR006027 Bedaquiline fumarate Bedaquiline fumarate Metabolite M2 Oxidation - N-demethylation Bedaquiline fumarate [1], [2]
References
1 Bedaquiline metabolism: enzymes and novel metabolites. Drug Metab Dispos. 2014 May;42(5):863-6.
2 Effects of Rifamycin Coadministration on Bedaquiline Desmethylation in Healthy Adult Volunteers

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