Details of the Metabolic Reaction (MR) | INTEDE

General Information of This Metabolic Reaction (MR) (ID: MR006032)
Formula
	Reactant	Belinostat		Product	3-ASBA (3-Anilino-Sulfonyl Benzene Carboxylic Acid)
	Reactant	Reactant Info		Product	Product Info

Other MR(s) Related to The Reactant of This MR

Other MR(s) That Metabolize The Reactant of This MR

MR ID	Reactant	Product	MR Type	Related Drug	REF
MR006033	Belinostat	Belinostat Acid	Unclear	Belinostat	[1]
MR006031	Belinostat	Belinostat Amide	Unclear	Belinostat	[1]
MR006030	Belinostat	Belinostat glucuronide	Conjugation - Glucuronidation	Belinostat	[2], [3]
MR006034	Belinostat	Methylated Belinostat	Unclear	Belinostat	[1]

References
1	Pharmacokinetics, metabolism, and excretion of (14)C-labeled belinostat in patients with recurrent or progressive malignancies
2	Glucuronidation by UGT1A1 is the dominant pathway of the metabolic disposition of belinostat in liver cancer patients. PLoS One. 2013;8(1):e54522.
3	In vitro characterization of belinostat glucuronidation: demonstration of both UGT1A1 and UGT2B7 as the main contributing isozymes

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