Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR006199)
Formula
SVG example
N-demethylation
Reactant Trimebutine Product Nortrimebutine
Reactant Info Product Info
Metabolic Type Oxidation - N-demethylation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR006204 Trimebutine 2-dimethylamino-2-phenylbutan-1-ol Hydrolysis - Hydrolysis Trimebutine [1], [2]
Other MR(s) Related to The Product of This MR
Other MR(s) That Metabolize The Produtc of This MR
MR ID Reactant Product MR Type Related Drug REF
MR006201 Nortrimebutine 2-methylamino-2-phenylbutan-1-ol Hydrolysis - Hydrolysis Trimebutine [1], [2], [3]
MR006200 Nortrimebutine N-didesmethyltrimebutine Oxidation - N-demethylation Trimebutine [1], [2], [3]
References
1 Studies of metabolic pathways of trimebutine by simultaneous administration of trimebutine and its deuterium-labeled metabolite
2 [Metabolism of trimebutine maleate, a gastrointestinal tract motility regulator in rats and mice: characterization and quantification of metabolites in urine, bile and plasma]
3 Quantitative determination of trimebutine maleate and its three metabolites in human plasma by liquid chromatography-tandem mass spectrometry

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