Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR006299)
Formula
SVG example
Reactant Fenethylline Metabolite M-1(AP ) Product Fenethylline Metabolite M-5( p-hydroxy-AP)
Reactant Info Product Info
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Produce The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR005723 Benzphetamine Amphetamine Unclear Benzphetamine [1]
MR004247 Etilamfetamine Amphetamine Unclear Etilamfetamine [2]
MR007177 Famprofazone Amphetamine Oxidation - N-dealkylation Famprofazone [3]
MR006298 Fenethylline Fenethylline Metabolite M-1(AP ) Unclear Fenethylline [4]
MR009984 Metamfetamine Amphetamine Unclear - Unclear Metamfetamine [5], [6], [7]
MR010000 Methamphetamine hydrochloride Amphetamine Unclear - Unclear Methamphetamine hydrochloride [5], [6], [7]
MR010844 Desmethyl selegiline Amphetamine Unclear - Unclear Selegiline [8]
MR007170 Methamphetamine Amphetamine Oxidation - N-demethylation Famprofazone [3]
MR010842 Methamphetamine Amphetamine Unclear - Unclear Selegiline [8]
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Other MR(s) Related to The Product of This MR
Other MR(s) That Produce The Product of This MR
MR ID Reactant Product MR Type Related Drug REF
MR000220 Amphetamine 4-hydroxyamphetamine Oxidation - Hydroxylation Amphetamine [9]
MR000810 Dextroamphetamine 4-hydroxyamphetamine Oxidation - Hydroxylation Dextroamphetamine [10]
MR005819 Methoxyamphetamine beta 4-hydroxyamphetamine Oxidation - #NAME? Methoxyamphetamine beta [11], [12]
MR009989 Amphetamine 4-Hydroxyamphetamine Unclear - Unclear Metamfetamine [13]
MR010005 Amphetamine 4-Hydroxyamphetamine Unclear - Unclear Methamphetamine hydrochloride [13]
MR006886 D-amphetamine 4-(2-Aminopropyl)phenol Oxidation - Oxidationn Lisdexamfetamine [14]
MR009992 P-hydroxymethamphetamine 4-Hydroxyamphetamine Unclear - Unclear Metamfetamine [13]
MR010008 P-hydroxymethamphetamine 4-Hydroxyamphetamine Unclear - Unclear Methamphetamine hydrochloride [13]
MR007171 Amphetamine p-Hydroxyamphetamine Oxidation - p-hydroxylation Famprofazone [3]
MR007174 p-Hydroxymethamphetamine p-Hydroxyamphetamine Oxidation - N-demethylation Famprofazone [3]
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Other MR(s) That Metabolize The Produtc of This MR
MR ID Reactant Product MR Type Related Drug REF
MR000809 4-hydroxyamphetamine 4-hydroxyamphetamine glucuronide Conjugation - Glucuronidation Dextroamphetamine [10]
MR000217 4-hydroxyamphetamine 4-hydroxynorephedrine Oxidation - Hydroxylation Amphetamine [15]
MR000808 4-hydroxyamphetamine Sulfated 4-hydroxyamphetamine Conjugation - Sulfation Dextroamphetamine [10]
MR006887 4-(2-Aminopropyl)phenol (-)-4-Hydroxynorephedrin Oxidation - Oxidationn Lisdexamfetamine [14]
MR009990 4-Hydroxyamphetamine 4-Hydroxynorephedrine Unclear - Unclear Metamfetamine [13]
MR010006 4-Hydroxyamphetamine 4-Hydroxynorephedrine Unclear - Unclear Methamphetamine hydrochloride [13]
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References
1 DrugBank(Pharmacology-Metabolism):Benzphetamine
2 The influence of diuretics on the excretion and metabolism of doping agents. III. Etilamfetamine. Arzneimittelforschung. 1986 Sep;36(9):1413-6.
3 Identification of new urinary metabolites of famprofazone in humans
4 Metabolic fate of fenetylline in rat and man
5 Sex- and dose-dependency in the pharmacokinetics and pharmacodynamics of (+)-methamphetamine and its metabolite (+)-amphetamine in rats
6 Drugs of abuse in a non-conventional sample; detection of methamphetamine and its main metabolite, amphetamine in abusers' clothes by HPLC with UV and fluorescence detection
7 Reduced CYP2D6 activity is a negative risk factor for methamphetamine dependence
8 Physiologically Based Pharmacokinetic Modeling of Transdermal Selegiline and Its Metabolites for the Evaluation of Disposition Differences between Healthy and Special Populations
9 Cytochromes P450: a structure-based summary of biotransformations using representative substrates Drug Metab Rev. 2008;40(1):1-100. doi: 10.1080/03602530802309742.
10 Clinical pharmacokinetics of amfetamine and related substances: monitoring in conventional and non-conventional matrices Clin Pharmacokinet. 2004;43(3):157-85. doi: 10.2165/00003088-200443030-00002.
11 Interactions of amphetamine analogs with human liver CYP2D6. Biochem Pharmacol. 1997 Jun 1;53(11):1605-12.
12 Interindividual and interspecies variation in the metabolism of the hallucinogen 4-methoxyamphetamine
13 Metabolism of ( 14 C)methamphetamine in man, the guinea pig and the rat
14 Preclinical pharmacokinetics, pharmacology and toxicology of lisdexamfetamine: a novel d-amphetamine pro-drug. Neuropharmacology. 2014 Dec;87:41-50.
15 DrugBank(Pharmacology-Metabolism)Amphetamine

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