Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR006460)
Formula Reactant SCH-417690 Product Vicriviroc N-oxide
Reactant Info Product Info
Metabolic Enzyme Cytochrome P450 3A4 (CYP3A4) DME Info
Cytochrome P450 3A5 (CYP3A5) DME Info
Metabolic Type Oxidation - N-oxidation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR006463 SCH-417690 21,22-HDoHE Unclear SCH-417690 [1]
MR006462 SCH-417690 N,N-Desalkylvicriviroc Unclear SCH-417690 [1]
MR006461 SCH-417690 N-Desalkylvicriviroc Unclear SCH-417690 [1]
MR006458 SCH-417690 O-Desmethylvicriviroc Oxidation - O-demethylation SCH-417690 [1]
MR006459 SCH-417690 Vicriviroc hydroxylamine Unclear SCH-417690 [1]
References
1 Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675.

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