Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR006488)
Formula
CYP3A4 ...
SVG example
Hydrolyzationn
Reactant VX-661 Product Tezacaftor metabolite M5
Reactant Info Product Info
Metabolic Enzyme Cytochrome P450 3A4 (CYP3A4) DME Info
Cytochrome P450 3A5 (CYP3A5) DME Info
Metabolic Type Oxidation - Hydrolyzationn
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR006486 VX-661 Tezacaftor metabolite M1 Oxidation - Hydrolyzationn VX-661 [1]
MR006487 VX-661 Tezacaftor metabolite M2 Oxidation - Hydrolyzationn VX-661 [1]
MR006489 VX-661 Tezacaftor metabolite M3 Conjugation - Glucuronidation VX-661 [2]
References
1 Bioactivity and metabolism of trans-resveratrol orally administered to Wistar rats
2 Symdeko FDA label

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