Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR006492)
Formula Reactant WSM-3978G Product Trans-hydroxyperhexilline
Reactant Info Product Info
Metabolic Enzyme Cytochrome P450 3A4 (CYP3A4) DME Info
Cytochrome P450 2B6 (CYP2B6) DME Info
Cytochrome P450 2D6 (CYP2D6) DME Info
Metabolic Type Oxidation - Aliphatic hydroxylation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR006490 WSM-3978G Cis-Hydroxy Perhexiline Oxidation - Hydrolyzationn WSM-3978G [1]
MR006491 WSM-3978G Monohydroxyperhexiline Oxidation - Hydrolyzationn WSM-3978G [1]
References
1 CYP2B6, CYP2D6, and CYP3A4 catalyze the primary oxidative metabolism of perhexiline enantiomers by human liver microsomes. Drug Metab Dispos. 2007 Jan;35(1):128-38.

If you find any error in data or bug in web service, please kindly report it to Dr. Yin and Dr. Li.