Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR006567)
Formula
CYP1A2 ...
SVG example
N-demethylation
Reactant Clomipramine hydrochloride Product Desmethylclomipramine
Reactant Info Product Info
Metabolic Enzyme Cytochrome P450 1A2 (CYP1A2) DME Info
Cytochrome P450 3A4 (CYP3A4) DME Info
Mephenytoin 4-hydroxylase (CYP2C19) DME Info
Metabolic Type Oxidation - N-demethylation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR006580 Clomipramine hydrochloride 10-OH-clomipramine Oxidation - Aliphatic hydroxylation Clomipramine hydrochloride [1]
MR006571 Clomipramine hydrochloride 2-hydroxyclomipramine Oxidation - 2-hydroxylation Clomipramine hydrochloride [2]
MR006574 Clomipramine hydrochloride 8-hydroxyclomipramine Oxidation - 8-hydroxylation Clomipramine hydrochloride [1]
MR006579 Clomipramine hydrochloride 8-OH-clomipramine Oxidation - Aromatic hydroxylation Clomipramine hydrochloride [2]
MR006578 Clomipramine hydrochloride Clomipramine N-oxide Oxidation - Oxidationn Clomipramine hydrochloride [1]
Other MR(s) Related to The Product of This MR
Other MR(s) That Produce The Product of This MR
MR ID Reactant Product MR Type Related Drug REF
MR009009 Clomipramine Desmethylclomipramine Oxidation - N-demethylation Clomipramine [3]
Other MR(s) That Metabolize The Produtc of This MR
MR ID Reactant Product MR Type Related Drug REF
MR006568 Desmethylclomipramine 2-hydroxydesmethyl clomipramine Oxidation - Demethylation Clomipramine hydrochloride [2]
MR006570 Desmethylclomipramine Didesmethylclomipramine Oxidation - N-demethylation Clomipramine hydrochloride [1], [4]
MR009010 Desmethylclomipramine Didesmethylclomipramine Oxidation - N-demethylation Clomipramine [3]
References
1 Metabolism of clomipramine in a Japanese psychiatric population: hydroxylation, desmethylation, and glucuronidation
2 Determination of clomipramine or imipramine and their mono-demethylated metabolites in human blood or plasma by high-performance liquid chromatography
3 Pharmacogenomics knowledge for personalized medicine Clin Pharmacol Ther. 2012 Oct;92(4):414-7. doi: 10.1038/clpt.2012.96.
4 Population pharmacokinetics of clomipramine, desmethylclomipramine, and hydroxylated metabolites in patients with depression receiving chronic treatment: model evaluation

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