Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR006616)
Formula Reactant Hydroxilated form of dolutegravir (M3) Product Hydrolized form of dolutegravir (M1)
Reactant Info Product Info
Metabolic Enzyme Cytochrome P450 1A1 (CYP1A1) DME Info
Cytochrome P450 1B1 (CYP1B1) DME Info
Metabolic Type Hydrolysis - Hydrolysis
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Produce The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR006614 Dolutegravir sodium Hydroxilated form of dolutegravir (M3) Oxidation - Hydrolyzationn Dolutegravir sodium [1]
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR006615 Hydroxilated form of dolutegravir (M3) 2,4- difluorobenzaldehyde (M5 dolutegravir) Hydrolysis - Hydrolysis Dolutegravir sodium [1]
References
1 Metabolism, excretion, and mass balance of the HIV-1 integrase inhibitor dolutegravir in humans

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