Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR006619)
Formula Reactant Dolutegravir sodium Product Defluorinated and gutathione conjugated form of dolutegravir (M4.2)
Reactant Info Product Info
Metabolic Type Multi-steps Reaction - Glutathione conjugation; oxidative defluorination
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR006618 Dolutegravir sodium Defluorinated and gutathione conjugated form of dolutegravir (M4.1) Multi-steps Reaction - Glutathione conjugation; oxidative defluorination Dolutegravir sodium [1]
MR006617 Dolutegravir sodium Ether glucuronide dolutegravir (M2) Conjugation - Glucuronidation Dolutegravir sodium [1]
MR006614 Dolutegravir sodium Hydroxilated form of dolutegravir (M3) Oxidation - Hydrolyzationn Dolutegravir sodium [1]
References
1 Metabolism, excretion, and mass balance of the HIV-1 integrase inhibitor dolutegravir in humans

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