Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR006675)
Formula
CBR1 ...
SVG example
Reactant Doxorubicin Product Doxorubicinol
Reactant Info Product Info
Metabolic Enzyme NADPH-dependent carbonyl reductase 1 (CBR1) DME Info
NADPH-dependent carbonyl reductase 3 (CBR3) DME Info
Aldo-keto reductase 1C3 (AKR1C3) DME Info
Aldo-keto reductase 1A1 (AKR1A1) DME Info
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR006678 Doxorubicin 7-deoxydoxorubicinolone Unclear Doxorubicin [1]
MR006676 Doxorubicin Doxorubicin-semiquinone Unclear Doxorubicin [2]
MR006673 Doxorubicin Doxorubicine hydroxyaglycone Unclear Doxorubicin [2]
MR006677 Doxorubicin Doxorubicinol deoxaglycone Unclear Doxorubicin [2]
Other MR(s) Related to The Product of This MR
Other MR(s) That Produce The Product of This MR
MR ID Reactant Product MR Type Related Drug REF
MR000095 Adriamycin Doxorubicinol Unclear Adriamycin [3]
References
1 Pharmacokinetics and metabolism of doxorubicin after short-term infusions in lymphoma patients
2 PharmGKB:Doxorubicin
3 Pharmacogenomics knowledge for personalized medicine Clin Pharmacol Ther. 2012 Oct;92(4):414-7. doi: 10.1038/clpt.2012.96.

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