Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR006704)
Formula
SVG example
O-dealkylation
Reactant N-debutyl-dronedarone Product Phenol-dronedarone
Reactant Info Product Info
Metabolic Enzyme Monoamine oxidase type A (MAO-A) DME Info
Metabolic Type Oxidation - O-dealkylation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Produce The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR006701 Dronedarone hydrochloride N-debutyl-dronedarone Oxidation - N-debutylation Dronedarone hydrochloride [1]
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR006702 N-debutyl-dronedarone Deaminated N,N-didebutyl-dronedarone Multi-steps Reaction - Deamination; debutylation Dronedarone hydrochloride [2]
MR006707 N-debutyl-dronedarone N,N'-didebutyl-dronedarone Oxidation - Debutylation Dronedarone hydrochloride [2]
MR006706 N-debutyl-dronedarone Propanoic acid-dronedarone Oxidation - Oxidationn deamination Dronedarone hydrochloride [2]
Other MR(s) Related to The Product of This MR
Other MR(s) That Metabolize The Produtc of This MR
MR ID Reactant Product MR Type Related Drug REF
MR006705 Phenol-dronedarone Phenol-dronedarone glucuronide Conjugation - Glucuronidation Dronedarone hydrochloride [2]
References
1 Identification of metabolic pathways and enzyme systems involved in the in vitro human hepatic metabolism of dronedarone, a potent new oral antiarrhythmic drug. Pharmacol Res Perspect. 2014 Jun;2(3):e00044.
2 DrugBank(Pharmacology-Metabolism):Dronedarone hydrochloride

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