Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR006754)
Formula
SVG example
Reactant 5-FU Product FdUMP
Reactant Info Product Info
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Produce The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR009800 5-FP 5-Fluoruracil (5-FU) Unclear - Unclear 5-FP [1]
MR010706 Emtricitabine Emtricitabine Metabolite M7 Unclear - Unclear Emtricitabine [2]
MR001058 Floxuridine 5-fluorouracil Unclear Floxuridine [3], [4]
MR006727 Flucytosine 5-FU Unclear Flucytosine [5]
MR009468 1-ethoxymethyl-5-fluorouracil 5-FU Unclear - Unclear EMITEFUR [6]
MR005270 5'-hydroxytegafur Fluorouracil Other reaction - Degradation Tegafur [7], [8]
MR005272 5-hydroxytegafur Fluorouracil Multi-steps Reaction - Hydrolysis; oxidation Tegafur-uracil [9]
MR002522 5'-DFUR 5-fluorouracil Hydrolysis - Hydrolysis Capecitabine [10], [11]
MR010337 5'-DFUR 5-FU Unclear - Unclear Galocitabine [12]
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Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR006748 5-FU FUrd Unclear Fluorouracilo [5]
MR001055 5-fluorouracil 5,6-Dihydro-5-fluorouracil Reduction - Reduction Floxuridine [3], [4]
MR006728 5-FU FUrd Unclear Flucytosine [5]
MR005277 Fluorouracil 5-fluorodeoxyuridine-monophosphate Conjugation - Phosphorylation Tegafur-uracil [9]
MR005278 Fluorouracil 5-fluorouridine-triphosphate Conjugation - Phosphorylation Tegafur-uracil [9]
MR005273 Fluorouracil 5-FUH2 Oxidation - Dehydrogenation Tegafur-uracil [9]
MR002524 5-fluorouracil FUH2 Reduction - Reduction Capecitabine [11]
⏷ Show the Full List of MR
Other MR(s) Related to The Product of This MR
Other MR(s) That Produce The Product of This MR
MR ID Reactant Product MR Type Related Drug REF
MR009770 NUC-3373 FdUMP Unclear - Unclear NUC-3373 [13]
MR006752 FdUDP FdUMP Unclear Fluorouracilo [5]
MR006732 FdUDP FdUMP Unclear Flucytosine [5]
References
1 Phase I clinical trial of 5-fluoro-pyrimidinone (5FP), an oral prodrug of 5-fluorouracil (5FU)
2 Hplc-nmr identification of the human urinary metabolites of (-)-cis-5-fluoro-1-[2-(hydroxymethyl)-1,3-oxathiolan-5-yl] cytosine, a nucleoside analogue active against human immunodeficiency virus (HIV)
3 Enhanced cancer cell growth inhibition by dipeptide prodrugs of floxuridine: increased transporter affinity and metabolic stability. Mol Pharm. 2008 Sep-Oct;5(5):717-27.
4 The achievement of mass balance by simultaneous quantification of floxuridine prodrug, floxuridine, 5-fluorouracil, 5-dihydrouracil, -fluoro--ureidopropionate, -fluoro--alanine using LC-MS J Chromatogr B Analyt Technol Biomed Life Sci. 2011 Apr 15;879(13-14):915-20. doi: 10.1016/j.jchromb.2011.02.045.
5 Study of the metabolism of flucytosine in Aspergillus species by 19F nuclear magnetic resonance spectroscopy
6 Phase I assessment of the pharmacokinetics, metabolism, and safety of emitefur in patients with refractory solid tumors
7 Summary of information on human CYP enzymes: human P450 metabolism data. Drug Metab Rev. 2002 Feb-May;34(1-2):83-448.
8 Roles of cytochromes P450 1A2, 2A6, and 2C8 in 5-fluorouracil formation from tegafur, an anticancer prodrug, in human liver microsomes. Drug Metab Dispos. 2000 Dec;28(12):1457-63.
9 DrugBank(Pharmacology-Metabolism):Tegafur-uracil
10 EUCRISA? (crisaborole) ointment, 2%, for topical use
11 A new, validated HPLC-MS/MS method for the simultaneous determination of the anti-cancer agent capecitabine and its metabolites: 5'-deoxy-5-fluorocytidine, 5'-deoxy-5-fluorouridine, 5-fluorouracil and 5-fluorodihydrouracil, in human plasma
12 Measurement of ascorbic acid in human aqueous humour and plasma and bovine aqueous humour by high-performance liquid chromatography with electrochemical detection
13 The novel anti-cancer fluoropyrimidine NUC-3373 is a potent inhibitor of thymidylate synthase and an effective DNA-damaging agent

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