Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR006768)
Formula Reactant Tofacitinib citrate Product Tofacitinib citrate metabolite M3
Reactant Info Product Info
Metabolic Type Oxidation - Oxidationn
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR006766 Tofacitinib citrate Tofacitinib citrate metabolite M1 Oxidation - Oxidationn Tofacitinib citrate [1]
MR006767 Tofacitinib citrate Tofacitinib citrate metabolite M2 Oxidation - Oxidationn Tofacitinib citrate [1]
MR006763 Tofacitinib citrate Tofacitinib citrate metabolite M6 Unclear Tofacitinib citrate [2]
References
1 Metabolic Activation of Tofacitinib Mediated by Myeloperoxidase in Vitro
2 Tofacitinib Is a Mechanism-Based Inactivator of Cytochrome P450 3A4

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