Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR006892)
Formula Reactant N-Desmethylamifloxacin Product Lomefloxacin glucuronide metabolite
Reactant Info Product Info
Metabolic Enzyme UDP-glucuronyltransferase (UGT) DME Info
Metabolic Type Conjugation - Glucuronidation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Produce The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR011860 Amifloxacin N-desmethyl-Amifloxacin Unclear - Unclear Amifloxacin [1]
MR006891 Lomefloxacin N-Desmethylamifloxacin Oxidation - N-demethylation Lomefloxacin [2]
References
1 In vitro activities of amifloxacin and two of its metabolites
2 Inhibitory potency of quinolone antibacterial agents against cytochrome P450IA2 activity in vivo and in vitro. Antimicrob Agents Chemother. 1992 May;36(5):942-8.

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