Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR006904)
Formula Reactant Desloratadine Product Desloratadine glucuronide
Reactant Info Product Info
Metabolic Enzyme UDP-glucuronosyltransferase 2B10 (UGT2B10) DME Info
Metabolic Type Conjugation - Glucuronidation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR000770 Desloratadine 5-hydroxydesloratadine Oxidation - Hydroxylation Desloratadine [1]
MR000771 Desloratadine 6-hydroxydesloratadine Oxidation - Hydroxylation Desloratadine [1]
MR000769 Desloratadine Desloratadine N-glucuronidation Conjugation - Glucuronidation Desloratadine [2], [1]
Other MR(s) Related to The Product of This MR
Other MR(s) That Metabolize The Produtc of This MR
MR ID Reactant Product MR Type Related Drug REF
MR006902 Desloratadine glucuronide 3-Hydroxydesloratadine Oxidation - 3-hydroxylation Loratadine [3]
References
1 A long-standing mystery solved: the formation of 3-hydroxydesloratadine is catalyzed by CYP2C8 but prior glucuronidation of desloratadine by UDP-glucuronosyltransferase 2B10 is an obligatory requirement Drug Metab Dispos. 2015 Apr;43(4):523-33. doi: 10.1124/dmd.114.062620.
2 Further characterization of the metabolism of desloratadine and its cytochrome P450 and UDP-glucuronosyltransferase inhibition potential: identification of desloratadine as a relatively selective UGT2B10 inhibitor. Drug Metab Dispos. 2015 Sep;43(9):1294-302.
3 Advances in high-resolution MS and hepatocyte models solve a long-standing metabolism challenge: the loratadine story. Bioanalysis. 2016 Aug;8(16):1645-62.

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