Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR006909)
Formula
CYP2D6 ...
SVG example
Hydrolyzationn
Reactant Lorcaserin Product 7-Hydroxylorcaserin
Reactant Info Product Info
Metabolic Enzyme Cytochrome P450 2D6 (CYP2D6) DME Info
Cytochrome P450 3A4 (CYP3A4) DME Info
Metabolic Type Oxidation - Hydrolyzationn
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR006907 Lorcaserin 1-Hydroxylorcaserin Oxidation - Hydrolyzationn Lorcaserin [1]
MR006908 Lorcaserin 5-Hydroxylorcaserin Oxidation - Hydrolyzationn Lorcaserin [1]
MR006911 Lorcaserin Lorcaserin metabolite M5 Unclear Lorcaserin [2]
MR006910 Lorcaserin Lorcaserin sulfamate Unclear Lorcaserin [2]
MR006906 Lorcaserin N-hydroxylorcaserin Oxidation - Hydrolyzationn Lorcaserin [1]
References
1 Identification of human cytochrome P450 and flavin-containing monooxygenase enzymes involved in the metabolism of lorcaserin, a novel selective human 5-hydroxytryptamine 2C agonist. Drug Metab Dispos. 2012 Apr;40(4):761-71.
2 DrugBank(Pharmacology-Metabolism):Lorcaserin

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