Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR007067)
Formula
SVG example
Reduction
Reactant Daidzein Product Dihydrodazein
Reactant Info Product Info
Metabolic Enzyme daidzein reductase (DZNR) DME Info
Metabolic Type Reduction - Reduction
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR007071 Daidzein 3',4',7-trihydroxyisoflavone Oxidation - Hydrolyzationn Daidzein [1]
MR007072 Daidzein Unclear Conjugation - Sulfation Daidzein [2]
Other MR(s) Related to The Product of This MR
Other MR(s) That Produce The Product of This MR
MR ID Reactant Product MR Type Related Drug REF
MR004169 Dihydrodaidzein Dihydrodaidzein Unclear Dihydrodaidzein [3]
MR008589 Puerarin metabolite M50 Dihydrodaidzein Reduction - Reduction Puerarin [4]
Other MR(s) That Metabolize The Produtc of This MR
MR ID Reactant Product MR Type Related Drug REF
MR007070 Dihydrodazein O-desmethylangolensin Unclear Daidzein [5]
MR007068 Dihydrodazein Tetrahydrodaidzein Unclear Daidzein [5]
References
1 Engineering of daidzein 3'-hydroxylase P450 enzyme into catalytically self-sufficient cytochrome P450. Microb Cell Fact. 2012 Jun 14;11:81.
2 Sulfation of environmental estrogens by cytosolic human sulfotransferases. Drug Metab Pharmacokinet. 2002;17(3):221-8.
3 R(-)-O-desmethylangolensin is the main enantiomeric form of daidzein metabolite produced by human in vitro and in vivo
4 Pharmacokinetics and drug delivery systems for puerarin, a bioactive flavone from traditional Chinese medicine
5 Metabolism of Daidzein and Genistein by Gut Bacteria of the Class Coriobacteriia

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