Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR007074)
Formula Reactant Dapoxetine Metabolite M1 Product Dapoxetine Metabolite M2
Reactant Info Product Info
Metabolic Type Oxidation - Hydrolyzationn
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Produce The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR007073 Dapoxetine Dapoxetine Metabolite M1 Oxidation - N-dealkylation Dapoxetine [1]
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR007076 Dapoxetine Metabolite M1 Desmethyldapoxetine Oxidation - Demethylation Dapoxetine [2], [3], [4]
Other MR(s) Related to The Product of This MR
Other MR(s) That Produce The Product of This MR
MR ID Reactant Product MR Type Related Drug REF
MR007078 Dapoxetine Metabolite M3 Dapoxetine Metabolite M2 Oxidation - Demethylation Dapoxetine [1]
Other MR(s) That Metabolize The Produtc of This MR
MR ID Reactant Product MR Type Related Drug REF
MR007075 Dapoxetine Metabolite M2 Dapoxetine Metabolite M9 Oxidation - Demethylation Dapoxetine [1]
References
1 Characterization of Phase I Hepatic Metabolites of Anti-Premature Ejaculation Drug Dapoxetine by UHPLC-ESI-Q-TOF
2 Dapoxetine: a new option in the medical management of premature ejaculation. Ther Adv Urol. 2012 Oct;4(5):233-51.
3 Effects of Evodiamine on the Pharmacokinetics of Dapoxetine and Its Metabolite Desmethyl Dapoxetine in Rats
4 Effects of 22 novel CYP2D6 variants found in Chinese population on the metabolism of dapoxetine

If you find any error in data or bug in web service, please kindly report it to Dr. Yin and Dr. Li.