Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR007110)
Formula Reactant Nordextropropoxyphene Product Dinordextropropoxyphene
Reactant Info Product Info
Metabolic Type Oxidation - N-demethyiation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Produce The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR007109 Dextropropoxyphene Nordextropropoxyphene Oxidation - N-demethyiation Dextropropoxyphene [1], [2]
References
1 CYP3A4 mediates dextropropoxyphene N-demethylation to nordextropropoxyphene: human in vitro and in vivo studies and lack of CYP2D6 involvement. Xenobiotica. 2004 Oct;34(10):875-87.
2 The role of CYP2D6 in primary and secondary oxidative metabolism of dextromethorphan: in vitro studies using human liver microsomes. Br J Clin Pharmacol. 1994 Sep;38(3):243-8.

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