Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR007144)
Formula Reactant 2-methoxyethinylestradiol Product 2-methoxyethinylestradiol-sulfate
Reactant Info Product Info
Metabolic Enzyme Sulfotransferase 1A1 (SULT1A1) DME Info
Sulfotransferase 1E1 (SULT1E1) DME Info
Metabolic Type Conjugation - Sulfation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Produce The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR002715 2-hydroxyethinylestradiol 2-methoxyethinylestradiol Conjugation - O-Methylation Ethinyl estradiol [1]
MR007142 Unclear 2-methoxyethinylestradiol Conjugation - O-methylation Ethinylestradiol propanesulfonate [1], [2]
MR001640 2-hydroxyethinylestradiol 2-methoxyethinylestradiol Conjugation - O-Methylation Mestranol [1], [2]
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR007143 2-methoxyethinylestradiol 2-methoxyethinylestradiol-glucuronide Conjugation - O-glucuronidation Ethinylestradiol propanesulfonate [1], [2]
References
1 Genetic variation in the first-pass metabolism of ethinylestradiol, sex hormone binding globulin levels and venous thrombosis risk Eur J Intern Med. 2017 Jul;42:54-60. doi: 10.1016/j.ejim.2017.05.019.
2 Metabolism of 17 alpha-ethinylestradiol by human liver microsomes in vitro: aromatic hydroxylation and irreversible protein binding of metabolites J Clin Endocrinol Metab. 1974 Dec;39(6):1072-80. doi: 10.1210/jcem-39-6-1072.

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