Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR007157)
Formula Reactant Ethinylestradiol propanesulfonate Product Ethinylestradiol-glucuronide
Reactant Info Product Info
Metabolic Enzyme UDP-glucuronosyltransferase 1A1 (UGT1A1) DME Info
UDP-glucuronosyltransferase 1A3 (UGT1A3) DME Info
UDP-glucuronosyltransferase 2B7 (UGT2B7) DME Info
UDP-glucuronosyltransferase 1A9 (UGT1A9) DME Info
Metabolic Type Conjugation - O-glucuronidation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR007158 Ethinylestradiol propanesulfonate Ethinylestradiol-3-sulfate Conjugation - Sulfation Ethinylestradiol propanesulfonate [1]
MR014077 Ethinylestradiol propanesulfonate Unclear Oxidation - 16alpha-hydroxylation Ethinylestradiol propanesulfonate [1], [2]
References
1 Genetic variation in the first-pass metabolism of ethinylestradiol, sex hormone binding globulin levels and venous thrombosis risk Eur J Intern Med. 2017 Jul;42:54-60. doi: 10.1016/j.ejim.2017.05.019.
2 Metabolism of 17 alpha-ethinylestradiol by human liver microsomes in vitro: aromatic hydroxylation and irreversible protein binding of metabolites J Clin Endocrinol Metab. 1974 Dec;39(6):1072-80. doi: 10.1210/jcem-39-6-1072.

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