Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR007389)
Formula
SVG example
O-demethylation
Reactant CBL-0102 M2 Product CBL-0102 M4
Reactant Info Product Info
Metabolic Type Oxidation - O-demethylation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Produce The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR007386 CBL-0102 CBL-0102 M2 Oxidation - N-desethylation CBL-0102 [1]
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR007387 CBL-0102 M2 CBL-0102 M3 Oxidation - N-desethylation CBL-0102 [1]
Other MR(s) Related to The Product of This MR
Other MR(s) That Produce The Product of This MR
MR ID Reactant Product MR Type Related Drug REF
MR007391 CBL-0102 M1 CBL-0102 M4 Unclear CBL-0102 [1]
References
1 Quinacrine is mainly metabolized to mono-desethyl quinacrine by CYP3A4/5 and its brain accumulation is limited by P-glycoprotein. Drug Metab Dispos. 2006 Jul;34(7):1136-44.

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