Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR007390)
Formula
SVG example
Reactant CBL-0102 Product CBL-0102 M1
Reactant Info Product Info
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR007386 CBL-0102 CBL-0102 M2 Oxidation - N-desethylation CBL-0102 [1]
MR007392 CBL-0102 CBL-0102 M6 Unclear CBL-0102 [1]
MR007393 CBL-0102 Unclear Oxidation - N-desethylation CBL-0102 [2]
Other MR(s) Related to The Product of This MR
Other MR(s) That Metabolize The Produtc of This MR
MR ID Reactant Product MR Type Related Drug REF
MR007391 CBL-0102 M1 CBL-0102 M4 Unclear CBL-0102 [1]
References
1 Quinacrine is mainly metabolized to mono-desethyl quinacrine by CYP3A4/5 and its brain accumulation is limited by P-glycoprotein. Drug Metab Dispos. 2006 Jul;34(7):1136-44.
2 The bacterial P450 BM3: a prototype for a biocatalyst with human P450 activities. Trends Biotechnol. 2007 Jul;25(7):289-98.

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