Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR007395)
Formula Reactant MDA Product HHA
Reactant Info Product Info
Metabolic Type Oxidation - O-demethylation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Produce The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR007394 CCRIS-9277 MDA Oxidation - O-demethylation CCRIS-9277 [1]
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR007403 MDA CCRIS-9277 M7 Oxidation - Deamination CCRIS-9277 [1]
Other MR(s) Related to The Product of This MR
Other MR(s) That Produce The Product of This MR
MR ID Reactant Product MR Type Related Drug REF
MR010012 Methyldopa Alpha-METHYLDOPAMINE Reduction - Decarboxylation Methyldopa [2]
MR008689 Methyldopate Hydrochloride Alpha-methyldopamine Reduction - Decarboxylation Methyldopate Hydrochloride [3], [4], [5], [6]
MR007406 HHMA HHA Oxidation - N-dealkylation CCRIS-9277 [1]
Other MR(s) That Metabolize The Produtc of This MR
MR ID Reactant Product MR Type Related Drug REF
MR008692 Alpha-methyldopamine 3-O-methyl-alpha-methyldopamine Conjugation - O-methylation Methyldopate Hydrochloride [7]
MR010013 Alpha-METHYLDOPAMINE Alpha-METHYLDOPAMINE SULFATE Unclear - Unclear Methyldopa [2]
MR008690 Alpha-methyldopamine Alpha-methylnorepinephrine Oxidation - Hydroxylation Methyldopate Hydrochloride [7]
MR007400 HHA CCRIS-9277 M4 Oxidation - Deamination CCRIS-9277 [1]
MR007402 HHA CCRIS-9277 M6 Conjugation - Sulfation CCRIS-9277 [1]
MR007407 HHA CCRIS-9277 M9 Conjugation - Sulfation CCRIS-9277 [1]
MR007396 HHA HMA Oxidation - Deamination CCRIS-9277 [1]
⏷ Show the Full List of MR
References
1 Human pharmacology of MDMA: pharmacokinetics, metabolism, and disposition. Ther Drug Monit. 2004 Apr;26(2):137-44.
2 Platelet phenol sulfotransferase and erythrocyte catechol-O-methyltransferase activities: correlation with methyldopa metabolism. Clin Pharmacol Ther. 1984 Jan;35(1):55-63.
3 Antihypertensive metabolites of alpha-methyldopa
4 Sulfate and methyldopa metabolism: metabolite patterns and platelet phenol sulfotransferase activity. Clin Pharmacol Ther. 1985 Mar;37(3):308-15.
5 The metabolism of 14 C-labelled -methyldopa in normal and hypertensive human subjects
6 THE METABOLISM OF METHYLDOPA IN HYPERTENSIVE HUMAN SUBJECTS
7 DrugBank(Pharmacology-Metabolism):Methyldopate Hydrochloride

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