Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR007415)
Formula
SVG example
Reactant Hydroquinone Product Ascorbate
Reactant Info Product Info
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR001158 Hydroquinone 2,3,5-tris(glutathion-S-yl)Hydroquinone Unclear Hydroquinone [1]
MR001157 Hydroquinone p-Benzoquinone Oxidation - Oxidation Hydroquinone [2]
MR007416 Hydroquinone Q acid I and Q acid II Unclear CoQ-10 [3]
MR006053 Hydroquinone Quinol glucuronide Conjugation - Conjugation ENT-1814 [4]
MR006052 Hydroquinone Quinol sulfate Conjugation - Conjugation ENT-1814 [4]
MR007414 Hydroquinone Tocopherol Unclear CoQ-10 [3]
MR008147 Hydroquinone Menatetrenone Unclear - Unclear Phytonadione [5]
Other MR(s) Related to The Product of This MR
Other MR(s) That Produce The Product of This MR
MR ID Reactant Product MR Type Related Drug REF
MR005328 Dehydroascorbate Ascorbic acid Reduction - Reduction Dehydroascorbate [6]
MR006283 L-Gulonate L-Ascorbate Unclear D-glucuronate [7]
MR006273 L-Gulonate L-Ascorbate Unclear D-glucose [7]
References
1 Carcinogenicity of a nephrotoxic metabolite of the "nongenotoxic" carcinogen hydroquinone Chem Res Toxicol. 2001 Jan;14(1):25-33. doi: 10.1021/tx000161g.
2 Hydroquinone, a bioreactive metabolite of benzene, inhibits apoptosis in myeloblasts Stem Cells. 1996 Nov;14(6):730-42. doi: 10.1002/stem.140730.
3 Coenzyme Q10: absorption, tissue uptake, metabolism and pharmacokinetics
4 Cytochrome P450 isozymes involved in the metabolism of phenol, a benzene metabolite. Toxicol Lett. 2001 Dec 15;125(1-3):117-23.
5 Recent trends in the metabolism and cell biology of vitamin K with special reference to vitamin K cycling and MK-4 biosynthesis
6 Structural insights into the dehydroascorbate reductase activity of human omega-class glutathione transferases. J Mol Biol. 2012 Jul 13;420(3):190-203.
7 Pleiotropic Actions of Aldehyde Reductase (AKR1A)

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