Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR007572)
Formula Reactant BRN-3548355 Product BRN-3548355 reactive intermediates
Reactant Info Product Info
Metabolic Enzyme Cytochrome P450 (CYP) DME Info
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR007570 BRN-3548355 NNAL Unclear BRN-3548355 [1], [2]
MR007573 BRN-3548355 Unclear Unclear BRN-3548355 [3]
MR014091 BRN-3548355 Unclear Unclear BRN-3548355 [3]
References
1 Toxicokinetic and Genotoxicity Study of NNK in Male Sprague Dawley Rats Following Nose-Only Inhalation Exposure, Intraperitoneal Injection, and Oral Gavage
2 Characterization of enzymes participating in carbonyl reduction of 4-methylnitrosamino-1-(3-pyridyl)-1-butanone (NNK) in human placenta. Chem Biol Interact. 2001 Jan 30;130-132(1-3):737-48.
3 4-(Methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) metabolism-related enzymes gene polymorphisms, NNK metabolites levels and urothelial carcinoma

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