Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR007831)
Formula	CTSA Peptide hydrolysis
	Reactant	Carfilzomib	Product	Carfilzomib metabolite M14
	Reactant	Reactant Info	Product	Product Info
Metabolic Enzyme	Cathepsin A (CTSA)				DME Info
Metabolic Type	Hydrolysis - Peptide hydrolysis

Other MR(s) Related to The Reactant of This MR

Other MR(s) That Metabolize The Reactant of This MR

MR ID	Reactant	Product	MR Type	Related Drug	REF
MR007830	Carfilzomib	Carfilzomib metabolite M15	Hydrolysis - Peptide hydrolysis	Carfilzomib	[1]
MR007826	Carfilzomib	Carfilzomib metabolite M16	Hydrolysis - Hydrolysis	Carfilzomib	[1]

Other MR(s) Related to The Product of This MR

Other MR(s) That Produce The Product of This MR

MR ID	Reactant	Product	MR Type	Related Drug	REF
MR007829	Carfilzomib metabolite M16	Carfilzomib metabolite M14	Unclear - Unclear	Carfilzomib	[1]
MR007828	Carfilzomib metabolite M15	Carfilzomib metabolite M14	Unclear - Unclear	Carfilzomib	[2]

References
1	Proteasome Inhibitors and Their Pharmacokinetics, Pharmacodynamics, and Metabolism Int J Mol Sci. 2021 Oct 27;22(21):11595. doi: 10.3390/ijms222111595.
2	Pharmacokinetics, pharmacodynamics, metabolism, distribution, and excretion of carfilzomib in rats

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