Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR007840)
Formula
SVG example
O-glucuronidation
Reactant 4-Hydroxypropofol Product 2,6-Diisopropyl-1,4-quinone
Reactant Info Product Info
Metabolic Enzyme Quinone reductase 1 (NQO1) DME Info
Metabolic Type Conjugation - O-glucuronidation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Produce The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR002187 Propofol 4-hydroxypropofol Oxidation - 4-Hydroxylation Propofol [1]
MR003261 Propofol 4-hydroxypropofol Oxidation - 4-Hydroxylation Fospropofol [1]
MR007835 Propofol 4-Hydroxypropofol Unclear - Unclear Fospropofol disodium [2]
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR002184 4-hydroxypropofol 1-Quinol glucuronide Conjugation - Glucuronidation Propofol [1]
MR002185 4-hydroxypropofol 4-Quinol glucuronide Conjugation - Glucuronidation Propofol [1]
MR002183 4-hydroxypropofol 4-Quinol sulfate Other reaction - Sulfonation Propofol [1]
MR007841 4-Hydroxypropofol 1-Hydroxypropofol-O-glucuronide Unclear - Unclear Fospropofol disodium [2]
MR007838 4-Hydroxypropofol 2-(omega-Propanol)-6-isopropyl-1,4-quinol Unclear - Unclear Fospropofol disodium [2]
MR007842 4-Hydroxypropofol 4-Hydroxypropofol-O-glucuronide Unclear - Unclear Fospropofol disodium [2]
MR007836 4-Hydroxypropofol 4-Hydroxypropofol-O-sulphate Unclear - Unclear Fospropofol disodium [2]
MR003253 4-hydroxypropofol 4-Quinol sulfate Other reaction - Sulfonation Fospropofol [1]
References
1 Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675.
2 Metabolic Profiles of Propofol and Fospropofol: Clinical and Forensic Interpretative Aspects

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