Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR007963)
Formula Reactant Loxoprofen cis-OH metabolite Product Loxoprofen gel metabolite M16
Reactant Info Product Info
Metabolic Enzyme UDP-glucuronosyltransferase 2B7 (UGT2B7) DME Info
Metabolic Type Unclear - Unclear
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Produce The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR007959 Loxoprofen gel Loxoprofen cis-OH metabolite Reduction - Reduction Loxoprofen gel [1], [2]
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR007961 Loxoprofen cis-OH metabolite Loxoprofen gel metabolite M11 Unclear - Unclear Loxoprofen gel [1]
MR007962 Loxoprofen cis-OH metabolite Loxoprofen gel metabolite M12 Unclear - Unclear Loxoprofen gel [1]
MR007960 Loxoprofen cis-OH metabolite Loxoprofen gel metabolite M6 Unclear - Unclear Loxoprofen gel [1]
Other MR(s) Related to The Product of This MR
Other MR(s) That Produce The Product of This MR
MR ID Reactant Product MR Type Related Drug REF
MR007958 Loxoprofen trans-OH metabolite Loxoprofen gel metabolite M16 Unclear - Unclear Loxoprofen gel [1], [2]
References
1 Identification of sulfonyl-loxoprofen as novel phase 2 conjugate in rat
2 Exploring the metabolism of loxoprofen in liver microsomes: the role of cytochrome P450 and UDP-glucuronosyltransferase in its biotransformation. Pharmaceutics. 2018 Aug 2;10(3). pii: E112.

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