Details of the Metabolic Reaction (MR) | INTEDE

General Information of This Metabolic Reaction (MR) (ID: MR008084)
Formula	CYP1A1 ... Oxidation
	Reactant	Sulindac		Product	Sulindac sulfone
	Reactant	Reactant Info		Product	Product Info
Metabolic Enzyme	Cytochrome P450 1A1 (CYP1A1)					DME Info
	Cytochrome P450 1A2 (CYP1A2)					DME Info
	Cytochrome P450 3A4 (CYP3A4)					DME Info
	Cytochrome P450 1B1 (CYP1B1)					DME Info
Metabolic Type	Oxidation - Oxidation

Other MR(s) Related to The Reactant of This MR

Other MR(s) That Metabolize The Reactant of This MR

MR ID	Reactant	Product	MR Type	Related Drug	REF
MR008083	Sulindac	Sulindac sulfide	Reduction - Reduction	Sulindac	[1], [2]

References
1	Studies on the metabolism and biological activity of the epimers of sulindac
2	Methionine Sulfoxide Reductase A in Human and Mouse Tissues is Responsible for Sulindac Activation, Making a Larger Contribution than the Gut Microbiota

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