Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR008098)
Formula
SVG example
Hydrolysis
Reactant Cyclacillin Product 6-APA
Reactant Info Product Info
Metabolic Type Hydrolysis - Hydrolysis
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR008097 Cyclacillin ACHC Hydrolysis - Hydrolysis Cyclacillin [1]
MR008095 Cyclacillin Cyclacillin penicilloic acid Unclear - Opening of the _x0002_lactam ring Cyclacillin [1]
Other MR(s) Related to The Product of This MR
Other MR(s) That Produce The Product of This MR
MR ID Reactant Product MR Type Related Drug REF
MR008130 Penicillin 6-aminopenicillanic acid Unclear - Unclear Penicillin [2], [3]
MR001971 Penicillin G 6-aminopenicillanic acid Unclear Penicillin G [4]
MR008106 Penicillin G Sodium 6-aminopenicillanic acid Hydrolysis - Hydrolysis Penicillin G Sodium [2]
MR008112 Penicillin V 6-aminopenicillanic acid Unclear - Unclear Penicillin V [5]
References
1 Sex- and species-related nephropathy of 6-(1-aminocyclohexanecarboxamido)penicillanic acid (cyclacillin) and its relationship to the metabolic disposition of the drug
2 Metabolism of penicillins to penicilloic acids and 6-aminopenicillanic acid in man and its significance in assessing penicillin absorption
3 Ligand-induced conformational change in penicillin acylase
4 McEvoy, G.K. (ed.). American Hospital Formulary Service - Drug Information 1999. Bethesda, MD:American Society of Health-System Pharmacists, Inc. 1999 (Plus Supplements)., p. 1760
5 Specificity of penicillin acylase of Fusarium and of Penicillium chrysogenum

If you find any error in data or bug in web service, please kindly report it to Dr. Yin and Dr. Li.