Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR008137)
Formula
SVG example
N-demethylation
Reactant Mepivacaine Product 2',6'-pipecoloxylidide
Reactant Info Product Info
Metabolic Type Oxidation - N-demethylation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR008136 Mepivacaine 2',6'-pipecoloxylidiae-3'-hydroxy-l-methyl Oxidation - Aromatic hydroxylations Mepivacaine [1]
MR008138 Mepivacaine 2',6'-pipecoloxylidide-4'-hydroxy-l-methyl Oxidation - Aromatic hydroxylations Mepivacaine [1]
Other MR(s) Related to The Product of This MR
Other MR(s) That Produce The Product of This MR
MR ID Reactant Product MR Type Related Drug REF
MR000481 Bupivacaine hydrochloride N-desbutylbupivacaine Unclear Bupivacaine hydrochloride [2]
MR001470 Levobupivacaine N-desbutylbupivacaine Unclear Levobupivacaine [3]
References
1 Clearance and metabolism of mepivacaine in the human neonate
2 Structural elucidation of phase I and II metabolites of bupivacaine in horse urine and fungi of the Cunninghamella species using liquid chromatography/multi-stage mass spectrometry Rapid Commun Mass Spectrom. 2012 Jun 15;26(11):1338-46. doi: 10.1002/rcm.6225.
3 Clinical profile of levobupivacaine in regional anesthesia: A systematic review. J Anaesthesiol Clin Pharmacol. 2013 Oct;29(4):530-9.

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