Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR008532)
Formula Reactant TH-302 metabolite RM8 Product TH-302 metabolite DM3
Reactant Info Product Info
Metabolic Type Hydrolysis - Hydrolysis
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Produce The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR008528 TH-302 metabolite RM7 TH-302 metabolite RM8 Hydrolysis - Hydrolysis TH-302 [1]
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR008531 TH-302 metabolite RM8 TH-302 metabolite DM4 Hydrolysis - Hydrolysis TH-302 [2]
MR008529 TH-302 metabolite RM8 TH-302 metabolite RM13 Conjugation - N-acetylation TH-302 [1]
References
1 Metabolism, pharmacokinetics and excretion of a novel hypoxia activated cytotoxic prodrug, TH-302, in rats
2 Metabolism and excretion of TH-302 in dogs

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